Protein Modification Reagents
Sigma Aldrich Fine Chemicals Biosciences Pepsin from porcine gastric mucosa, 9001-75-6, MFCD00081840, 25g
Powder, ≥250 units/mg solid, Synonym: Pepsin A, Pepsin from hog stomach; Pepsin is a peptidase used to digest proteins and is commonly used in the preparation of Fab fragments from antibodies.
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 1 G
Biotin-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to harness the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting a protein of interest.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Facilitates selective degradation of target proteins
- Engages the ubiquitin-proteasome system
eMolecules Fmoc-NH-PEG6-CH2COOH | 437655-96-4 | MFCD26142983 | 1g
Broadpharm | Fmoc-NH-PEG6-CH2COOH | 1g | 340377165 | BP-23534 | 95.000 | 437655-96-4 | MFCD26142983 | 561.628 | C29H39NO10
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Biotium MUC5AC (Mucin 5AC / Gastric Mucin)(2-12M1), CF740 conjugate, 0.1mg/mL
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is located in the N-terminal cysteine rich part of the peptide core of MUC5AC, which is heavily glycosylated. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. MAb 2-11M1 reacts with the protein backbone exclusively; it only reacts with fully deglycosylated MUC5AC. Therefore, the material under test should also be fully deglycosylated. This can be achieved with standard periodate oxidation method. The success of the deglycosylation can be checked with routine PAS (Periodic Acid Shiff) staining. After deglycosylation, the preparation should no longer be stainable with PAS reagent. Only then 2-11M1 will react should MUC5AC be present. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may b
Medchemexpress LLC 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane | 55400-73-2 | 95.0% | 350.41 | 1 G
Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Sigma Aldrich Fine Chemicals Biosciences Pepsin Reagent Ready to Us
PEPSIN Pepsin Reagent Ready to Us
Sigma Aldrich Fine Chemicals Biosciences Collagenase B from Clostri
Collagenase B is prepared from Clostridium histolyticum cultures by filtration ammonium sulfate precipitation dialysis and lyophilization. Collagenase from Clostridium histolyticum is a collagenolytic enzyme. It interacts with collagen-like substances and is responsible for the degradation of collagen into small peptides. It is widely used for the disaggregation of many types of tissues (e.g. lung heart muscle bone adipose tissue liver kidney cartilage mammary gland placentae blood vessels brain tumors) and for the preparation of single-cell suspensions for the establishment of primary cell culture systems. Collagenase B is recommended when yield and viability are important.
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 5 G
Biotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTAC
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
eMolecules m-PEG24-alcohol | 9004-74-4 | MFCD27977524 | 1g
Broadpharm | m-PEG24-alcohol | 1g | 229582254 | BP-22074 | 97.000 | 9004-74-4 | MFCD27977524 | 1089.314 | C49H100O25
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eMolecules Propargyl-PEG1-SS-alcohol | 1391914-41-2 | MFCD28505558 | 1g
Broadpharm | Propargyl-PEG1-SS-alcohol | 1g | 550804207 | BP-22670 | 98.000 | 1391914-41-2 | MFCD28505558 | 192.290 | C7H12O2S2
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eMolecules endo-BCN-PEG3-amine | | | 500mg
Broadpharm | endo-BCN-PEG3-amine | 500mg | 528284354 | BP-24510 | 98.000 | | | 368.474 | C19H32N2O5
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Medchemexpress LLC Mal-amido-PEG2-C2-acid | 756525-98-1 | 99.8% | 328.32 | 250 MG
Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins
Ubpbio TCEP SOLUTION (1M), 10ML
Protein Purification Reagents – TCEP solution (1M) (UBPBio catalog# P1021-10, P1020-100) – TCEP (tris(2-carboxyethyl)phosphine) is a strong reducing agent. Compared to dithiothreitol (DTT) and β-mercaptoethanol, TCEP has the advantages of being odorless, a more powerful reducing agent, an irreversible reducing agent, more hydrophilic, and more resistant to oxidation in air. It is soluble in water and stable at neutral pH. It does not reduce metals used in immobilized metal affinity chromatography such as Ni-NTA resin. TCEP is particularly useful when labeling cysteine residues with maleimides.