Protein Modification Reagents
eMolecules 1352827-47-4 | Fmoc-PEG3-NHS ester | Broadpharm | MFCD28142471 | 540.569 | C28H32N2O9 | 0.000 | O=C(CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12)ON1C(=O)CCC1=O | 1g | 263744723
Fmoc-PEG3-NHS ester | Broadpharm | 1352827-47-4 | MFCD28142471 | 540.569 | C28H32N2O9 | 0.000 | O=C(CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12)ON1C(=O)CCC1=O | 1g | 263744723
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA | 1662687-83-3 | 98.9% | 590.63 | C27H38N6O9 | 5 MG
Mal-PEG2-Val-Cit-PABA is a cleavable antibody-drug conjugate (ADC) linker designed for synthesis of ADCs. It features a maleimide reactive handle, a PEG2 spacer for improved hydrophilicity, and a Val-Cit-PABA cleavage motif that enables protease-mediated release of payloads in target cells.
- Cleavable Val-Cit-PABA motif for protease-triggered payload release.
- Maleimide functional group for thiol-selective conjugation to antibodies.
- PEG2 spacer increases hydrophilicity and may reduce aggregation.
- High chemical purity suitable for research and ADC synthesis.
- Stable when stored as powder at -20°C; follow recommended solvent storage conditions.
Medchemexpress LLC BCN-endo-PEG2-maleimide | 2675364-08-4 | 98.1% | 475.53 | C24H33N3O7 | 25 MG
A bifunctional linker reagent containing an endo-bicyclononyne reactive group and a maleimide separated by a PEG2 spacer, designed for strain-promoted azide-alkyne cycloaddition and thiol conjugation in bioconjugation and drug-delivery workflows.
- Contains endo-bicyclononyne and maleimide reactive groups.
- Peg2 spacer provides flexibility and solubility.
- Enables catalyst-free strain-promoted azide-alkyne cycloaddition (SPAAC) with azides.
- Compatible with maleimide-mediated thiol conjugation.
- High purity and defined molecular weight for reproducible conjugation.
eMolecules 1807537-41-2 | AZD-PEG2 -PFP | Broadpharm | MFCD27635165 | 572.485 | C26H25F5N2O7 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)c(F)c1F | 100mg | 229582342
AZD-PEG2 -PFP | Broadpharm | 1807537-41-2 | MFCD27635165 | 572.485 | C26H25F5N2O7 | 98.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)c(F)c1F | 100mg | 229582342
Medchemexpress LLC N3-PEG2-C2-NHS ester | 1312309-64-0 | MFCD20926376 | ≥98.0% | 300.27 | C11H16N4O6 | 250 MG
N3-PEG2-C2-NHS ester is an azide-functionalized PEG2 NHS ester linker used for bioconjugation and the synthesis of antibody-drug conjugates. The molecule contains an NHS ester for coupling to primary amines and an azide group enabling click chemistry (copper-catalyzed azide-alkyne cycloaddition and strain-promoted cycloaddition). It is provided as a high-purity liquid and is soluble in DMSO for research-scale conjugation.
- Azide-functionalized PEG2 linker for click chemistry
- NHS ester for efficient amine coupling
- High purity (≥98.0%) for reliable conjugation
- Soluble in DMSO (approx. 100 mg/mL) for stock solutions
- Stable when stored dry at -20°C for extended periods
Medchemexpress LLC Mal-PEG2-oxyamine | 1146245-73-9 | MFCD00209801 | 95.0% | 244.24 g·mol⁻¹ | C10H16N2O5 | 5 MG
Mal-PEG2-oxyamine is a PEG-based bifunctional linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It contains a maleimide group and an oxyamine moiety separated by a PEG2 spacer, enabling thiol-maleimide coupling and oxime ligation for efficient bioconjugation. The free base can be prone to instability; a TFA salt is available to improve stability.
- Bifunctional maleimide and oxyamine reactive groups.
- PEG2 spacer provides flexibility and improved solubility.
- Compatible with thiol conjugation and oxime ligation chemistries.
- Offered as a small-scale reagent (e.g., 5 mg) with reported purity around 95%.
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 250 MG
Bis-PEG4-PFP ester is a PROTAC linker that is PEG-based and can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Consists of two distinct ligands connected by a linker
- Targets an E3 ubiquitin ligase with one ligand
- Targets a specific protein with the other ligand
- Leverages the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
eMolecules 2101563-45-3 | Fmoc-NH-PEG10-CH2CH2COOH | MFCD28122954 | 1g
ChemScene | Trimethyl ethane-112-tricarboxylate | 25g | 536866145 | CS-W023095 | 40967-67-7 | MFCD00015619 | 204.178 | C8H12O6
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Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 g/mol | C22H35NO8 | 100 MG
endo-BCN-PEG4-acid is a BCN-containing PEG4 linker used for click chemistry and bioconjugation, typically employed in the synthesis of antibody-drug conjugates (ADCs) via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Cleavable four-unit PEG linker suitable for ADC and PROTAC synthesis.
- Contains a strained BCN moiety for efficient SPAAC with azide-containing partners.
- High purity for conjugation applications.
- Liquid form, colorless to light yellow, with recommended low-temperature storage.
- Available as a 100 MG pack for laboratory use.
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB | 1949793-41-2 | 98.9% | 777.86 | C36H55N7O12 | 50 MG
Mal-PEG4-Val-Cit-PAB is a cleavable antibody-drug conjugate (ADC) linker containing a maleimide thiol-reactive group, a PEG4 spacer, a Val-Cit dipeptide, and a p-aminobenzyl (PAB) spacer. It is used to attach cytotoxic payloads to antibodies via a protease-cleavable linker for ADC synthesis.
- Cleavable Val-Cit-PAB protease-sensitive spacer.
- Maleimide thiol-reactive group for antibody conjugation.
- PEG4 spacer improves solubility and flexibility.
- High purity (approximately 98.9%).
- Solid, white to off-white; molecular weight 777.86 g/mol.
- Storage: sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Azide-PEG-amine (MW 5000) | 95.0% | N₃(CH₂CH₂O)nNH₂ | 50 MG
Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Facilitates protein degradation via PROTACs
- White to off-white solid appearance
- Average molecular weight of 5000
STA PHARMACEUTICAL US LLC FmocNH-PEG8-CH2CH2COOH | 5 g | CAS 756526-02-0 | MDL MFCD11041143
FmocNH-PEG8-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 756526-02-0
- MDL: MFCD11041143
- InChIKey: VYXGUCLTEWCVRY-UHFFFAOYSA-N
- Molecular Weight: 663.761
- Molecular Formula: C34H49NO12
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | 100.0% | 1083.12 g/mol | C54H63FN8O15 | 5 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugate (ADC) research that couples a cleavable GGFG peptide-PEG4 linker with a propargyl handle to the DXd topoisomerase I inhibitor. It is supplied as an off-white to light yellow solid, with high purity and DMSO solubility for use in conjugation and payload studies.
- High purity, 99.99% (HPLC)
- Molecular weight 1083.12 g/mol
- Chemical formula C54H63FN8O15
- Physical appearance: solid, off-white to light yellow
- Storage: 4°C as supplied; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
- Solubility: DMSO up to 100 mg/mL (use ultrasonic)
- Intended use: research use only for ADC linker-payload development
Medchemexpress LLC Dspe-peg2000-maleimide | 00-00-0 | 99.6% | C53H99N4O14P | 10MG
DSPE-PEG2000-Maleimide is a phospholipid-polyethylene glycol conjugate with a terminal maleimide group that enables covalent attachment to thiol-containing ligands. It incorporates into lipid bilayers to produce targeted liposomes and lipid nanoparticles, supporting targeted delivery research and ligand-directed surface modification.
- Terminal maleimide for specific thiol coupling.
- Amphiphilic lipid anchor for stable liposome insertion.
- PEG2000 spacer reduces opsonization and extends circulation time.
- High purity suitable for research applications (>99.5%).
- Soluble in DMF and DMSO with recommended handling procedures.
- Storage under nitrogen at -20°C; in solvent storage at -80°C extends stability.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG4-CH2COOH | 10 g | CAS 437655-95-3 | MDL MFCD26142981
Fmoc-NH-PEG4-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 437655-95-3
- MDL: MFCD26142981
- InChIKey: XPNLDOFYRFOXLR-UHFFFAOYSA-N
- Molecular Weight: 473.522
- Molecular Formula: C25H31NO8
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid
- SMILES: O=C(COCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O